Biodegradable, non-thrombogenic elastomeric polyurethanes
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsYi Hong, William R Wagner, Sang-Ho Ye
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Abstract
A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.
Claims29
A method of forming an implantable article, comprising:
- providing a biodegradable polymer comprising anti-thrombogenic zwitterionic groups at least one of within a backbone of the biodegradable polymer or pendant upon the backbone of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups reactive with reactive functional groups on a surface of the implantable article;
- and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article to covalently bond the biodegradable polymer to the implantable article.
An implantable article, comprising:
- a biodegradable polymer comprising anti-thrombogenic groups comprising zwitterionic groups at least one of in a backbone of the biodegradable polymer or pendant upon the backbone of the biodegradable polymer and biodegradable groups in the backbone of the biodegradable polymer, the biodegradable polymer being covalently bonded to a surface of the implantable article.
A method of forming an implantable article, comprising:
- forming the implantable article from a biodegradable polymer comprising anti-thrombogenic zwitterionic groups at least one within a backbone of the biodegradable polymer or pendant upon the backbone of the biodegradable polymer and biodegradable groups in the backbone of the biodegradable polymer.
Dependencies are inferred from the claim text.