Tubular silk compositions and methods of use thereof
AssigneesTrustees of Tufts College, The Trustees of Columbia University in the City of New York, Massachussets Institute of Technology
InventorsMichael L. Lovett, Xianyan Wang, Christopher M. Cannizzaro, Gordana Vunjak-Novakovic, David L. Kaplan
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Abstract
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
Claims23
A tubular composition in which a silk fibroin material forms a wall that defines an inner lumen having a diameter of less than 6 mm, and has a structure, including pore size, wherein the tubular composition achieves a burst strength of at least 1680 mm Hg, and wherein said wall has an apparent permeability coefficient of 7.3×10−4+/−1.5×10−4 cm/s or lower.
Dependencies are inferred from the claim text.