Biocompatible and biodegradable elastomer
AssigneeNational Taiwan University
InventorsShan-hui Hsu, Kun-Che Hung
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Abstract
The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier.
Claims14
A biocompatible and biodegradable elastomer, comprising:
- a main chain of polyurethane comprising a hard segment and a soft segment, the hard segment is formed by reaction of diisocyanate, 2,2-bis(hydroxymethyl)propionic acid and a chain extender, and the soft segment is a biodegradable oligomer diol, wherein the biodegradable oligomer diol is a combination consisting of 40˜96 mol % polycaprolactone diol and 4˜60 mol % polylactic acid diol, a combination consisting of 94˜96 mol % polycaprolactone diol and 4˜6 mol % poly(ethylene glycol) diol or a combination consisting of 78˜84 mol % polycaprolactone diol, 12˜18 mol % poly-DL-lactic acid diol and 4˜6 mol % poly(ethylene glycol) diol;
- wherein the polylactic acid diol has a molecular weight of 1040-2520 g/mol and poly(ethylene glycol) diol has a molecular weight of 1450-2400 g/mol;
- and
- wherein the molar ratio of diisocyanate:soft segment:2,2-bis(hydroxymethyl)propionic acid:chain extender is 3-4:1:1-2:1.52.
Dependencies are inferred from the claim text.