Haemostatic wound dressing

A kit for formation of a haemostatic wound dressing, which comprises a non-colloidal porous dressing material, and, separately, a haemostatic agent comprising a plurality of carriers and a plurality of fibrinogen-binding peptides immobilized to each carrier, wherein each fibrinogen-binding peptide comprises:

• an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO:
• 1) at an amino terminal end of the peptide, wherein Xaa is any amino acid other than Val;
• or an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO:
• 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro;
• wherein the non-colloidal porous dressing material comprises a sheet, pad, sponge, foam, film, gauze, mesh, granules or beads, wherein if the non-colloidal porous dressing material comprises granules or beads, a majority of the granules or beads have a maximum dimension that is greater than 6 μm;
• and wherein the plurality of carriers are immobilized to the non-colloidal porous dressing material, and the plurality fibrinogen binding peptides are covalently immobilized to each carrier.

A haemostatic wound dressing, which comprises a non-colloidal porous dressing material, and a plurality of fibrinogen-binding peptides immobilized to the non-colloidal porous dressing material, wherein each fibrinogen-binding peptide comprises:

• an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO:
• 1) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Val;
• or
• an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO:
• 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro,
• wherein the non-colloidal porous dressing material comprises granules or beads, wherein a majority of the granules or beads have a maximum dimension that is greater than 6 μm, and
• wherein the plurality of fibrinogen binding peptides are covalently immobilized to the non-colloidal porous dressing material.

A kit for formation of a haemostatic wound dressing, which comprises a non-colloidal porous dressing material, and, separately, a haemostatic agent comprising a plurality of fibrinogen-binding peptides, wherein each fibrinogen-binding peptide comprises:

• an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO:
• 1) at an amino terminal end of the peptide, wherein Xaa is any amino acid other than Val;
• or an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO:
• 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro;
• wherein the non-colloidal porous dressing material comprises granules or beads, wherein a majority of the granules or beads have a maximum dimension that is greater than 6 μm;
• and wherein the fibrinogen-binding peptides are covalently immobilized to the non-colloidal porous dressing material.