Contrast agent for nuclear magnetic resonance imaging comprising melanin nanoparticles stably dispersed in water
AssigneeMelanis Co., Ltd.
InventorsJin Kyu Lee, Kuk Youn Ju, Jung Hee Lee
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Abstract
The present invention relates to a contrast agent for nuclear magnetic resonance imaging, and more particularly, to a contrast agent for nuclear magnetic resonance imaging containing melanin nanoparticles having a uniform shape and size, thereby providing good dispersibility in water, no cell toxicity, and a long retention time in vivo.
Claims33
A contrast agent for nuclear magnetic resonance imaging, comprising:
- melanin nanoparticles having stable dispersibility in water;
- and
- paramagnetic metal ions which are coordinated on the surface of the melanin nanoparticles.
A method for preparing a contrast agent for nuclear magnetic resonance imaging comprising melanin nanoparticles having stable dispersibility in water and paramagnetic metal ions which are coordinated on the surface of the melanin nanoparticles, the method comprising:
- adding a solution containing paramagnetic metal ions to a solution containing melanin nanoparticles to form coordinate bonds between the paramagnetic metal ions and melanin of the melanin nanoparticles, and forming melanin nanoparticles having stable dispersibility in water.
Dependencies are inferred from the claim text.