Conjugates for protection from nephrotoxic active substances
AssigneeMerck Patent GmbH
InventorsArmin Kuebelbeck, Gregor Larbig, Stefan Arnold, Walter Mier, Uwe Haberkorn
Life of this patent
Estimating the term…
Abstract
The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.
Claims7
A conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds,
- wherein the at least one kidney-selective carrier molecule is
- an oligopeptide comprising multiple monomeric peptides comprising more than 50% (based on the number of amino acid units) of sequence sections selected from the group consisting of -(KKEEE)-, -(RREEE)-, -(KKKEEE)- and -(KKKEE)-, wherein
- (i) the peptide or oligopeptide overall has a chain length of 15 to 100 amino acid units;
- (ii) the peptide or oligopeptide comprises at least 50% (based on the number of amino acid units) of amino acids K and E, or R and E, respectively;
- and
- (iii) the oligopeptide comprises at least 3 consecutive sequence sections;
- wherein the at least one active compound is selected from the group consisting of lipoic acid, resveratrol, caffeic acid, luteolin, quercetin, rutin, cyanidin, xanthohumol, ascorbic acid, nicotinic acid, amifostin, alliin, thiols, tocopherols, carotinoids, butylhydroxytoluene (BHT), pifithrin-μ, pifithrin-α, MDL 28170 and NS3694, and combinations thereof.
Dependencies are inferred from the claim text.