Compounds and compositions for the treatment of ocular disorders

A compound of Formula:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• L1 is selected from:
• L2 is selected from:
• A is selected from:
• H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, and alkyloxy;
• R1, R2, and R3 are selected from:
• —C(O)R4, C(O)A, and hydrogen wherein either R1 or R2 cannot be hydrogen and wherein R1, R2, and R3 can be further optionally substituted with R5;
• R4 is selected from:
• (i) —C10-C30alkylR5, —C10-C30alkenylR5, —C10-C30alkynylR5, —C10-C30alkenylalkynylR5, —C10-C30alkyl, —C10-C30alkenyl, —C10-C30alkynyl, and —C10-C30alkenylalkynyl;
• or
• (ii) an unsaturated fatty acid residue selected from linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, stearidonic acid, y-linolenic acid, arachidonic acid, docosatetraenoic acid, palmitoleic acid, vaccenic acid, paullinic acid, oleic acid, elaidic acid, gondoic acid, nervonic acid and mead acid;
• and
• R5 is selected from:
• halogen, hydroxyl, cyano, mercapto, amino, aryl, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, —S(O)2alkyl, —S(O)alkyl, —P(O)(Oalkyl)2, B(OH)2, —Si(CH3)3, —COOH, —COOalkyl, —CONH2.