Method of using salmon thrombin to alleviate central nervous system-mediated pain
AssigneeSea Run Holdings, Inc.
InventorsBeth A. Winkelstein, Paul A. Janmey, Evelyn S. Sawyer
Life of this patent
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Abstract
A method of alleviating central nervous system-mediated pain includes applying salmon thrombin at a neural injury site. Applying salmon thrombin can include applying a gel that includes salmon thrombin. The gel can also include fibrinogen, for example, salmon fibrinogen, human fibrinogen, or bovine fibrinogen. The salmon thrombin can be obtained from salmon plasma, or using recombinant technology, or by fractionation. A pain relief substance includes a gel that includes salmon thrombin.
Claims22
A method of alleviating central nervous system-mediated pain, comprising applying salmon thrombin at a neural injury site, thereby diminishing a degree of nerve sensitivity to pain experienced at the site, wherein diminishing a degree of nerve sensitivity to pain experienced at the site includes reducing an inflammatory response at the site.
A method of alleviating central nervous system-mediated pain, comprising applying salmon thrombin at a neural injury site, thereby diminishing a degree of nerve sensitivity to pain experienced at the site, wherein diminishing a degree of nerve sensitivity to pain experienced at the site includes reducing activation of microglia at the site.
Dependencies are inferred from the claim text.