Anti-cell proliferative compounds and methods of use
AssigneeKALOS Therapeutics
InventorMichael Kozlowski
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Abstract
The invention provides compounds such as proteins, peptides, peptidomimetics and small molecules, methods for treating cell proliferative disorders such as neoplasia, tumor, or cancer, and metastasis thereof, and methods for identifying and screening for active compounds.
Claims12
An isolated or purified compound having anti-cell proliferative activity, wherein the compound consists of an 8 to about 45 amino acid residue sequence and wherein the 8 to about 45 amino acid residue sequence includes the sequence F-K-G-Q-L-R-X-I (SEQ ID NO:
- 1911), wherein X is A, F, I, K, M, N, P, R, T, W, or Y.
An isolated or purified compound having anti-cell proliferative activity, wherein the compound consists of an 8 to about 45 amino acid residue sequence which includes within the sequence an 8 reside sequences selected from:
- L-K-G-Q-L-R-C-I (SEQ ID NO:
- 1908), or L-G-G-F-L-R-C-I (SEQ ID NO:
- 1909).
Dependencies are inferred from the claim text.