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US 9,808,507 B2Granted
Anti-c-Met/anti-Ang2 bispecific antibody
AssigneeSamsung Electronics Co., Ltd.
InventorsSeungja Oh, Kyung Ah Kim, Bo Gyou Kim, Seung Hyun Lee, Ji Min Lee
Life of this patent
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Abstract
An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.
Claims13
An anti-c-Met/anti-Ang2 bispecific antibody comprising (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, wherein
- the anti-c-Met antibody or antigen-binding fragment thereof comprises (i) a heavy chain variable region comprising (a) a CDR-H1 comprising SEQ ID NO:
- 1, 22, 23, or 24, (b) a CDR-H2 comprising SEQ ID NO:
- 2, 25, or 26, and (c) a CDR-H3 comprising SEQ ID NO:
- 3, 27, 28, or 85, and (ii) a light chain variable region comprising (a) a CDR-L1 comprising an SEQ ID NO:
- 10, 29, 30, 31, 32, 33 or 106, (b) a CDR-L2 comprising SEQ ID NO:
- 11, 34, 35, or 36, and (c) a CDR-L3 comprising SEQ ID NO:
- 12, 13, 14, 15, 16, 37, 86, or 89;
- and the anti-Ang-2 antibody or antigen-binding fragment thereof comprises:
- (i) a heavy chain variable region comprising (a) a CDR-H1 comprising SEQ ID NO:
- 109, (b) a CDR-H2 comprising SEQ ID NO:
- 128, and (c) a CDR-H3 comprising SEQ ID NO:
- 111, and (ii) a light chain variable region comprising a CDR-L1 comprising SEQ ID NO:
- 129, a CDR-L2 comprising SEQ ID NO:
- 130, and a CDR-L3 comprising SEQ ID NO:
- 131.
12 more elements
Dependencies are inferred from the claim text.