Compositions comprising semaphorins for the treatment of cancer and methods of selection thereof
AssigneeRappaport Family Institute for Research in the Medical Sciences
InventorsGera Neufeld, Boaz Kigel, Ofra Kessler, Asya Varshavsky
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Abstract
A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.
Claims15
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an amino acid sequence at least 89% identical to the sequence set forth in SEQ ID NO:
- 32, thereby treating the cancer.
A method of treating cancer by inhibiting angiogenesis to a tumor in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an amino acid sequence at least 89% identical to the sequence set forth in SEQ ID NO:
- 32, thereby treating the cancer.
Dependencies are inferred from the claim text.