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US 9,808,490 B2Granted
Induced hepatocytes and uses thereof
AssigneeAccelerated Biosciences Corp.
InventorsJau-Nan Lee, Tony Tung-Yin Lee, Yuta Lee, Eing-Mei Tsai
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Abstract
Disclosed herein are induced hepatocytes from a trophoblast stem cell, methods for inducing the cells, and compositions thereof. Also disclosed herein are methods of treating a disease or disorder (e.g., liver-associated) by utilizing an induced hepatocyte disclosed herein.
Claims26
A method of inducing a trophoblast stem (TS) cell to differentiate into an induced hepatocyte in vitro, comprising:
- contacting the trophoblast stem cell with a fibroblast growth factor (FGF) that binds to FGFR1 to induce formation of a definitive endoderm (DE) cell, and
- contacting the DE cell with a medium to induce differentiation into an induced hepatocyte,
- wherein the medium comprises a FGF that binds to FGFR1, a glucocorticoid steroid, and an interleukin 6 group cytokine.
Dependencies are inferred from the claim text.