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US 9,808,486 B2Granted
Administration of kynurenine depleting enzymes for tumor therapy
AssigneeBoard of Regents, The University of Texas System
InventorsGeorge Georgiou, Everett Stone
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Abstract
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
Claims16
A method of treating a subject having a tumor comprising administering to the subject an effective amount of a pharmaceutical formulation comprising:
- (i) a kynureninase polypeptide comprising the sequence set forth by SEQ ID NOs:
- 7, 8, 10-52 or 57;
- or
- (ii) a kynureninase polypeptide comprising a sequence having at least 95% identity to SEQ ID NOs:
- 7, 8, 10-52 or 57, wherein said polypeptide has kynureninase activity
- and a pharmaceutically acceptable carrier.
3 more elements
Dependencies are inferred from the claim text.