Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsJames Francis Dropinski, Milana Maletic, Jae-Hun Kim, Deyou Sha
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Abstract
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof wherein: R1 is halo; —CN; alkyl; cycloalkyl; alkoxy; phenyl, which is optionally substituted one or twice independently by alkyl, halo, or —CN; or a thiophene ring, which is optionally substituted once or twice independently by alkyl. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
Claims13
A compound of the formula
- or a pharmaceutically acceptable salt thereof
- wherein:
- R1 is halo;
- —CN;
- alkyl;
- cycloalkyl;
- alkoxy;
- phenyl, which is optionally substituted one or twice independently by alkyl, halo, or —CN;
- or a thiophene ring, which is optionally substituted once or twice independently by alkyl.
Dependencies are inferred from the claim text.