Emulsion formulations of aprepitant
AssigneeHeron Therapeutics, Inc.
InventorsThomas B. Ottoboni, Han Han
Life of this patent
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Abstract
Disclosed herein are novel pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. Also included are formulations including both aprepitant and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.
Claims15
A method for preventing or treating a subject at risk of or suffering from emesis, comprising administering to the subject a composition comprising an injectable physically stable emulsion wherein the emulsion comprises:
- aprepitant;
- 11 wt/wt % to 15 wt/wt % of an emulsifier;
- an oil;
- a co-emulsifier which is an alcohol;
- a tonicity modifier;
- a pH modifier;
- and water;
- wherein the ratio of emulsifier:aprepitant ranges from about 18:1 to 22:1, and
- wherein the pH of the emulsion ranges from about 7.5 to 9.0.
Dependencies are inferred from the claim text.