Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Benedikt Vollrath, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Abstract
Disclosed herein are auris acceptable gel compositions containing a multiparticulate glutamate receptor antagonist, and methods for the treatment of otic diseases or conditions through intratympanic administration of the composition to an individual afflicted with an otic disease or condition.
Claims17
An intratympanic composition for use in the treatment of otic disorders by intratympanic administration on or near the round window membrane of the ear, the pharmaceutical composition comprising an auris acceptable gel and a multiparticulate non-microencapsulated glutamate receptor antagonist, wherein sustained release of the glutamate receptor antagonist into the cochlea occurs for a period of at least 3 days.
Dependencies are inferred from the claim text.