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US 9,808,454 B2Granted
Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
AssigneeAmpio Pharmaceuticals, Inc.
InventorsDavid Bar-Or, Greg Thomas
Life of this patent
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Abstract
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
Claims26
A method of expanding bone marrow derived mesenchymal stem cells, comprising
- (a) contacting the mesenchymal stem cells with DA-DKP, wherein the DA-DKP is in a composition comprising a less than 5000 molecular weight fraction of human serum albumin, and
- (b) culturing the stem cells under conditions suitable to facilitate the expansion of the mesenchymal stem cells.
A method of providing mammalian bone marrow derived mesenchymal stem cells to a mammal, comprising:
- (a) contacting the mesenchymal stem cells with DA-DKP, wherein the DA-DKP is in a composition comprising a less than 5000 molecular weight fraction of human serum albumin,
- (b) cultivating the mesenchymal stem cells under conditions suitable to facilitate the expansion of the cells;
- and
- (c) introducing the expanded cells into a mammal.
1 more element
A method of causing bone marrow derived mesenchymal stem cells to differentiate into a particular type of cell comprising:
- (a) contacting the mesenchymal stem cells with DA-DKP, wherein the DA-DKP is in a composition comprising a less than 5000 molecular weight fraction of human serum albumin;
- (b) cultivating the mesenchymal stem cells under conditions suitable to facilitate the expansion of the stem cells;
- and
- (c) adding one or more differentiation factors or changing culturing conditions to induce differentiation of the mesenchymal stem cells to form a different type of cell.
1 more element
A method of providing differentiated cells, to a mammalian subject, comprising:
- (a) contacting mammalian multipotent bone marrow derived mesenchymal stem cells with DA-DKP, wherein the DA-DKP is in a composition comprising a less than 5000 molecular weight fraction of human serum albumin;
- (b) cultivating the mesenchymal stem cells under conditions suitable to facilitate the expansion of the mesenchymal stem cells;
- (c) adding one or more differentiation factors or changing culturing conditions to induce differentiation of cells to form a different type of cell;
- and
- (d) introducing the differentiated cells into the subject.
2 more elements
Dependencies are inferred from the claim text.