Antiproliferative compounds and methods of use thereof

A pharmaceutical composition comprising a compound of Formula I:

• or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate, thereof, wherein:
• R1 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl;
• R2 and R3 are each halo;
• where the substituents on R1, when present, are one to three groups Q, where each Q is independently alkyl, halo, haloalkyl, alkoxyalkyl, oxo, hydroxyl, alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, —R4OR5, —R4OR5—R4OR5, —R4N(R6)(R7), —R4SR5, —R4OR4N(R6)(R7), —R4OR4C(J)N(R6)(R7), —C(J)R9 or R4S(O)tR8;
• each R4 is independently alkylene, alkenylene or a direct bond;
• each R5 is independently hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl or heterocyclylalkyl, where alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl or heterocyclylalkyl groups in R5 are each independently optionally substituted with 1-3 Q1 groups, where each Q1 is independently alkyl, haloalkyl or halo;
• R6 and R7 are selected as follows:
• i) R6 and R7 are each independently hydrogen or alkyl;
• or
• ii) R6 and R7 together with the nitrogen atom on which they are substituted form a 5 or 6-membered heterocyclyl or heteroaryl ring, optionally substituted with one or two halo, alkyl or haloalkyl;
• R8 is alkyl, haloalkyl, or hydroxyalkyl;
• R9 is alkyl or aryl;
• J is O or S;
• and
• t is 1 or 2.