Factor IXa inhibitors

A compound of the Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• n is an integer of 0 or 1;
• p is an integer of 0 to 5;
• q is an integer of 0 to 4;
• r is an integer of 0 to 4;
• X is a nitrogen atom or CH;
• Y is an oxygen atom, a sulfur atom or NH (when n=0), Y is a nitrogen atom or CH (when n=1);
• Z1, Z2, Z3, and Z4 are each independently a nitrogen atom or CH;
• each R1 is a halogen atom, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a hydroxyl C1-6 alkyl group, a C3-12 cycloalkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C2-7 alkanoyl group, or a group of —NRARB;
• RA and RB are each independently a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group or a C2-7 alkanoyl group;
• each R2 is independently a halogen atom, a cyano group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C3-12 cycloalkyl group, a C1-6 alkoxy group, or a halogenated C1-6 alkoxy group;
• each R3 is independently a halogen atom, a cyano group, a C1-6 alkyl group, a C3-12 cycloalkyl group, a halogenated C1-6 alkyl group, a hydroxy C1-6 alkyl group, a cyanated C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a halogenated C1-6 alkoxy group, a C2-7 alkanoyl group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, or a group of —NRARB, or oxo;
• a dotted line in a bicyclic substructure of Formula (I) represented by Formula (II):
• represents a single bond when n is 0, or a double bond when n is 1;
• a substructure of ring A represented by Formula (III):
• is a non aromatic heterocyclic group selected from:
• is heteroaryl.