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US 9,808,428 B2Granted
Compositions and methods for the delivery of therapeutics
AssigneeBoard of Regents of the University of Nebraska
InventorsHoward E. Gendelman, Xin-Ming Liu
Life of this patent
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Abstract
The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
Claims25
A nanoparticle consisting of at least one CCR5 receptor antagonist, at least one hydrophobic polymer, and at least one surfactant.
A nanoparticle comprising at least one CCR5 receptor antagonist, at least one hydrophobic polymer, and at least one surfactant,
- wherein said at least one surfactant is a mixture of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), and 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG), wherein at least one of DSPE, DSPC, and DSPG is conjugated to polyethylene glycol.
Dependencies are inferred from the claim text.