Targeted liposomes in cancer therapy
AssigneeWestern University of Health Sciences
InventorsMaria Polikandritou Lambros, Ying Huang, Hari Chandana Mulamalla
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Abstract
The invention provides pharmaceutical compositions containing a vehicle for the targeted delivery of therapeutic and diagnostic agents for the treatment of hyperproliferative diseases. The targeting component of the vehicle is a cystine molecule that is coupled to the cargo component, which can be either a therapeutic or diagnostic agent or to a nanoparticle composition that contains the therapeutic agent or diagnostic. The invention also provides methods of treating hyperproliferative disorders by targeting hyperproliferative disease cells for the targeted delivery of a therapeutic or diagnostic agent.
Claims8
A vehicle for the targeted intracellular delivery of a therapeutic agent or a diagnostic agent, or both, the vehicle comprising a cystine molecule coupled to a cargo, wherein the cargo is a liposome composition comprising a therapeutic agent, a diagnostic agent, or both, wherein the cystine is a targeting component.
A pharmaceutical formulation comprising:
- a) a vehicle for the targeted intracellular delivery of a therapeutic agent, a diagnostic agent, or both, the vehicle comprising a cystine molecule coupled to a cargo for intracellular delivery, wherein the cargo is a liposome composition comprising a therapeutic agent, a diagnostic agent, or both, wherein the cystine is a targeting component;
- and
- b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.