Preparation of suspension aerosol formulations
AssigneeGenerics [UK] Limited
InventorsLi Li Bovet, Jay T. Holt
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Abstract
The present invention provides processes for preparing suspension aerosol formulations, wherein the particles for inhalation are formed in situ during the process of manufacturing the formulation. In one aspect of the invention, a process for preparing a suspension aerosol formulation comprises the steps of: (a) dissolving one or more medicaments in one or more solvents to form a solution; and (b) mixing one or more propellants with the solution under conditions effective to precipitate, entirely or partially, at least one of the medicaments.
Claims59
A method of preparing a suspension aerosol formulation comprising a particulate medicament and a propellant, wherein a medicament solution is mixed with the propellant under conditions that cause a precipitate of the medicament to be formed from the solution, wherein the medicament solution is mixed with the propellant in an aerosol canister, and wherein the precipitate comprises particles of the medicament in a form suitable for use in inhalation therapy.
Dependencies are inferred from the claim text.