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US 9,808,420 B2Granted
Drug delivery devices for delivery of ocular therapeutic agents
AssigneeNovaer Holdings, Inc.
InventorsCasey Kopczynski, Cheng-Wen Lin, Chris Sutay
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Abstract
Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and a recess configured to support the composition. At least one of the portions includes an impermeable polymer and at least one other portion includes a rate-limiting water-permeable polymer. The rate-limiting water-permeable polymer allows for transportation of the active agent to an exterior of the device.
Claims8
A device, comprising:
- a composition in the form of a matrix of an active agent and a non-water soluble polymer, wherein the active agent comprises a latanoprost free acid salt, and wherein the non-water soluble polymer comprises ethylene vinyl acetate,
- a first polymer portion;
- a second polymer portion fused to the first polymer portion, the second polymer portion including a recess configured to support the composition;
- and
- a third polymer portion fused to the second polymer portion;
- wherein the total diameter of the device ranges from 3-5 mm, and
- wherein the device is configured to:
- (a) conform to a curvature of the eye,
- (b) yield an elution rate of 0.00025-0.0075 micrograms/hr of the active agent, and
- (c) release 70% to 90% of the active agent over a period of at least 30 days.
7 more elements
Dependencies are inferred from the claim text.