Biomarker-based methods for formulating compositions that improve skin quality and reduce the visible signs of aging in skin for individuals in a selected population
AssigneeThe Procter & Gamble Company
InventorsQing Stella, Karl Shiqing Wei, Cynthia Ann Garza, Kenneth Robert Wehmeyer, Rohan Lalith Wimalasena
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Abstract
In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin in a select population, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality in the population as evidenced by one or more biomarker changes that correlate with improvement as evidenced by one or more objective measurements of skin health in the population.
Claims6
A method of identifying a rinse off personal care composition as effective for improving the stratum corneum barrier in a human subject who is a member of a selected population of subjects, comprising:
- (a) generating one or more control skin profiles for two or more subjects in a select population of subjects wherein the subjects in the select population have dry or damaged skin;
- (b) contacting at least a portion of skin of the subjects with a rinse-off test composition, rinsing the test composition off the portion of skin, extracting one or more skin samples from each of the subjects, and generating from the extracted samples one or more test profiles for the subjects;
- (c) comparing the one or more test profiles to the one or more control profiles and identifying the rinse-off test composition as effective for improving the stratum corneum barrier in a human subject who is a member of a selected population of subjects if the test profile is directionally shifted away from the control profile and shows (i) a decrease in one or more inflammatory cytokines, (ii) an increase in one or more natural moisturizing factors, (iii) an increase in one or more lipids, and (iv) a decrease in total protein.
The method according to any one of the preceding claims, wherein the steps are repeated for a different target population.
Dependencies are inferred from the claim text.