Customized surgical guides, methods for manufacturing and uses thereof

A combination of a bone implant and a surgical guide for placement on a bone of a patient comprising:

• a bone implant having an external morphology at least a portion of which functionally replaces an original anatomical feature of at least a portion of the patient's bone, and
• a surgical guide for surgical instruments for placement on said bone implant, the surgical guide comprising:
• (i) one or more surface structures comprising one or more flanges extending over at least part of said external morphology of the bone implant, wherein said external morphology of said bone implant has a surface that is complementary with a surface of said one or more surface structures and wherein a contact area between the one or more surface structures of the surgical guide and the surface of the bone implant has a three-dimensional fit that prevents both uni- or bi-directional translation along a first axis and uni- or bi-directional rotation around a second axis, so as to allow a stable fit between said surgical guide and said bone implant,
• (ii) one or more guiding elements, wherein said one or more guiding elements are selected from the group consisting of drill guiding elements and cutting guiding elements, and
• (iii) a central connecting structure that interconnects said one or more surface structures and said one or more guiding elements.