Tissue resection devices and related methods

A method of operating a medical device, comprising:

• deploying a snare about tissue of a patient, wherein the snare includes a delivery member having at least two lumens extending therethrough, each lumen of the at least two lumens including a rotational element therein, wherein the rotational element in each of the at least two lumens includes at least one of a female helical groove and a helical mandrel, wherein each rotational element is configured to convert linear motion into rotational motion, and a snare element including a distal snare loop and two proximally extending legs, wherein each leg is within one of the at least two lumens, wherein the snare loop includes a first side wire portion and a second side wire portion opposite the first side wire portion on opposite sides of a longitudinal axis of the snare element;
• applying an axially directed force so as to impart clock-wise rotation of the first side wire portion about an axis of the first side wire portion and counter clock-wise rotation of the second side wire portion about an axis of the second side wire portion to expand or retract the distal snare loop.