Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

A method of calibrating a sensor during a period of sensor transition, the method comprising:

• defining an electrochemical impedance spectroscopy (EIS)-based sensor status vector (V) for each one of a plurality of sensor current (Isig)-blood glucose (BG) pairs;
• defining an Isig buffer to store Isig values of said plurality of Isig-BG pairs;
• defining an BG buffer to store BG values of said plurality of Isig-BG pairs;
• monitoring the status vectors for the plurality of Isig-BG pairs over time;
• detecting when there is a difference between a first status vector for a first Isig-BG pair and a subsequent status vector for a subsequent Isig-BG pair;
• if a magnitude of said difference is smaller than a predetermined threshold, calibrating said sensor based on values of said Isig-BG pairs from a first set of Isig and BG buffers;
• and
• if the magnitude of said difference is larger than a predetermined threshold, calibrating said sensor based on values of said Isig-BG pairs from a second set of Isig and BG buffers, wherein said second set of Isig and BG buffers contains at least the values of Isig and BG from said subsequent Isig-BG pair.