Pentacyclic triterpene compounds and uses thereof
AssigneeBiovectra Inc.
InventorsJohn G. Riley, Richard J. Bethell
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Abstract
Disclosed herein is a PEGylated bis pentacyclic triterpene, compositions comprising the PEGylated bis pentacyclic triterpene, methods of preparing the PEGylated bis pentacyclic triterpene, and a method of treating or preventing a fungal disease in a plant using the compounds and compositions disclosed herein. The PEGylated bis pentacyclic triterpene has the formula A-P-B, wherein A is a first pentacyclic triterpene; B is a second pentacyclic triterpene; and P is a polyethylene glycol (PEG) molecule.
Claims14
A PEGylated bis pentacyclic triterpene having the formula:
- A---P---B,
- wherein,
- A is a first pentacyclic triterpene;
- B is a second pentacyclic triterpene;
- and
- P is a polyethylene glycol (PEG) molecule with an average molecular weight of from about 400 daltons (Da) to about 8000 Da, for use in treating a fungal disease in a plant, wherein the fungal disease is blight;
- said first and second pentacyclic triterpenes are each independently betulin, betulinic acid, or lupeol;
- and
- A and B are each independently covalently bound to P by an ester linkage at C3 or C28.
A method of treating a fungal disease in a plant, wherein the fungal disease is blight, said method comprising:
- applying to the plant, to a soil supporting the plant, or to both the plant and the soil supporting the plant, a composition comprising:
- a PEGylated bis pentacyclic triterpene having the formula:
- A---P---B,
- wherein,
- A is a first pentacyclic triterpene;
- B is a second pentacyclic triterpene;
- and
- P is a polyethylene glycol (PEG) molecule with an average molecular weight of from about 400 daltons (Da) to about 8000 Da;
- and
- an agriculturally acceptable diluent;
- wherein the first and second pentacyclic triterpenes are each independently betulin, betulinic acid, or lupeol;
- and
- wherein A and B are each independently linked to P by an ester linkage at C3 or C28.
Dependencies are inferred from the claim text.