Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) with plume capture by continuous flow solvent probe
AssigneeThe Regents of the University of California
InventorsJeremy T. O'Brien, Evan R. Williams, Hoi-Ying N. Holman
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Abstract
A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a Fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mM nicotine and is ˜50%. This transfer efficiency is significantly higher than values reported for similar techniques.
Claims6
A system for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) comprising an infrared microscope with an infinity-corrected reflective objective, an infrared laser, a continuous flow solvent probe coupled to a mass spectrometer having an electrospray ionization emitter, and a stage for the sample to be subjected to laser ablation mass spectrometry.
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