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US 9,804,417 B2Granted
Wettable silicone hydrogel contact lenses and related compositions and methods
AssigneeCooperVision International Holding Company, LP
InventorsYe Hong, Charlie Chen, Nick Manesis
Life of this patent
Estimating the term…
Abstract
Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.
Claims20
A method for producing a silicone hydrogel contact lens, comprising:
- providing a polymerizable silicone hydrogel lens precursor composition in a contact lens shaped cavity of a non-polar resin contact lens mold, the polymerizable silicone hydrogel precursor composition comprising a silicone-containing component and a non-silicone containing component, the non-silicone containing component being present in an amount between about 10% to about 60% (w/w) based upon the weight of all reactive components of the precursor composition and said non-silicone containing component comprising an N-vinyl pyrrolidone (NVP) monomer and a N,N-dimethylacrylamide (DMA) monomer, and the contact lens mold comprising a first contact lens mold member and a second contact lens mold member assembled together;
- polymerizing the polymerizable silicone hydrogel lens precursor composition in the non-polar resin contact lens mold using heat or ultraviolet light to form a pre-extracted polymerized silicone hydrogel contact lens product having a dry weight, the pre-extracted silicone hydrogel contact lens product having a removable monomeric component in an amount of at least 10% (w/w) based on the dry weight of the pre-extracted polymerized silicone hydrogel contact lens product;
- extracting and hydrating the pre-extracted polymerized silicone hydrogel contact lens product by contacting the pre-extracted polymerized silicone hydrogel contact lens product with an extraction media to produce a silicone hydrogel contact lens having a dry weight no greater than 90% of the dry weight of the pre-extracted polymerized silicone hydrogel contact lens product;
- and
- packaging the silicone hydrogel contact lens in a contact lens package,
- wherein the silicone hydrogel contact lens has an advancing contact angle less than 90 degrees, a tensile modulus less than 1.0 MPa, an oxygen permeability from about 110 barrers to about 120 barrers, and a water content from about 45% to about 55% by weight.
3 more elements
A silicone hydrogel contact lens, comprising:
- a lens body having a dry weight no greater than 90% of the dry weight of the lens body prior to an extraction, wherein said lens body had at least 10% (w/w) of a removable monomeric component removed based on the dry weight of the lens body prior to removal, and wherein said lens body comprises a polymerized silicone hydrogel precursor composition comprising a silicone-containing component and a non-silicone containing component, the non-silicone containing component being present in an amount between about 10% to about 60% (w/w) based upon the weight of all reactive components of the precursor composition and comprising an N-vinylpyrrolidone (NVP) monomer and a N,N-dimethylacrylamide (DMA) monomer, and wherein the lens body is a cast molded element obtained from a non-polar resin contact lens mold polymerized using heat or ultraviolet light, wherein the silicone hydrogel contact lens has an advancing contact angle less than 90 degrees, a tensile modulus less than about 1.0 MPa, an oxygen permeability from about 110 barrers to about 120 barrers, and a water content from about 45% to about 55% by weight.
A silicone hydrogel contact lens, comprising:
- a lens body having a dry weight no greater than 90% of the dry weight of the lens body prior to an extraction, wherein said lens body had at least 10% (w/w) of a removable monomeric component removed based on the dry weight of the lens body prior to removal, and wherein said lens body comprises a polymerized silicone hydrogel precursor composition comprising a silicone-containing component and a non-silicone containing component, the silicone-containing component comprises a silicone monomer, a silicone macromer, or a silicone prepolymer, or combinations thereof, each of said silicone monomer, said silicone macromer, or silicone prepolymer comprising a polymerizable functional group, said polymerizable functional group being a methacrylate functional group or an acrylamide functional group, the non-silicone containing component being present in an amount between about 10% to about 60% (w/w) based upon the weight of all reactive components of the precursor composition and comprising an N-vinylpyrrolidone (NVP) monomer and a N,N-dimethylacrylamide (DMA) monomer, and wherein the lens body is a cast molded element obtained from a non-polar resin contact lens mold polymerized using heat or ultraviolet light, wherein the silicone hydrogel contact lens has an advancing contact angle less than 90 degrees, a tensile modulus less than about 1.0 MPa, an oxygen permeability from about 110 barrers to about 120 barrers, and a water content from about 45% to about 55% by weight.
Dependencies are inferred from the claim text.