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US 9,804,158 B2Granted
Peptides and methods for the detection of Leishmaniasis
AssigneesInstitut De Recherche Pour Le Developpement, Universidad Peruana Cayetano Heredia
InventorsJorge Arevalo, Eric Deharo, Angela Privat-Maldonado
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Abstract
The present invention relates to peptides and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, especially infection with a South American strain causing the American Tegumentary Leishmaniasis (ATL).
Claims3
In vitro diagnostic method for the detection of the presence or absence of antibodies indicative of a South American Leishmania strain responsible for the American Tegumentary Leishmaniasis, comprising the steps of:
- a) contacting H2A-P9 (SEQ. ID. NO. 9) and P2a-P6 (SEQ. ID. NO. 67) with a biological sample for a time and under conditions sufficient to form a first immune complex comprising a first antibody bound to SEQ. ID. NO. 9 and a second immune complex comprising a second antibody bound to SEQ. ID. NO. 67;
- and
- b) detecting the presence or absence of the first immune complex and second immune complex formed in a)
- wherein detecting the presence of the first immune complex and the second immune complex indicates the presence of antibodies indicative of a South American Leishmania strain.
1 more element
Dependencies are inferred from the claim text.