Magnetic removal or identification of damaged or compromised cells or cellular structures
AssigneeInguran, LLC
InventorKristie Marie Krug
Life of this patent
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Abstract
A method for magnetic cellular manipulation may include contacting a composition with a biological sample to form a mixture. The composition may include a plurality of particles. Each particle in the plurality of particles may include a magnetic substrate. The magnetic substrate may be characterized by a magnetic susceptibility greater than zero. The composition may also include a chargeable silicon-containing compound. The chargeable silicon-containing compound may coat at least a portion of the magnetic substrate. The biological sample may include cells and/or cellular structures. The method may also include applying a magnetic field to the mixture to manipulate the composition.
Claims4
A method for magnetic cellular separation, the method comprising:
- contacting a composition with a biological sample to form a mixture, the composition comprising particles, wherein each particle is no greater than 1000 nm and is comprised of:
- i) a magnetic substrate, the magnetic substrate characterized by a magnetic susceptibility greater than zero;
- and ii) a chargeable silicon-containing compound, the chargeable silicon-containing compound coating at least a portion of the magnetic substrate;
- and the biological sample comprising viable sperm cells and damaged or dead sperm cells, the particles binding to the damaged or dead sperm cells solely through an electrical charge interaction;
- applying a magnetic field to the mixture;
- and
- separating the damaged or dead sperm cells from the viable sperm cells.
Dependencies are inferred from the claim text.