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US 9,803,249 B2Granted
Detecting neoplasm
AssigneeMayo Foundation for Medical Education and Research
InventorsWilliam R. Taylor, Jonathan J. Harrington, Patrick S. Quint, Hongzhi Zou, Harold S. Bergen, III, David I. Smith, David A. Ahlquist
Life of this patent
Estimating the term…
Abstract
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
Claims5
A method for characterizing a human biological sample comprising:
- (a) measuring a K-ras mutation score from a human biological sample, wherein said measuring of said K-ras mutation score is measured by digital melt curve analysis;
- (b) measuring a methylation level of a CpG site of from the human biological sample;
- (c) determining whether or not the human biological sample has an elevated K-ras mutation score and an elevated BMP3 methylation status as compared to a control from a subject that does not have premalignant or malignant colorectal cancer.
A method for characterizing a human stool sample comprising:
- (a) measuring a K-ras mutation score from a human stool sample;
- (b) measuring a methylation level of a CpG site of BMP3 from the human stool sample;
- (c) determining whether or not the stool biological sample has an elevated K-ras mutation score and an elevated BMP3 methylation status as compared to a control from a subject that does not have premalignant or malignant colorectal cancer.
Dependencies are inferred from the claim text.