Methods of determining eosinophilic gastritis status based on marker or gene expression

A method of determining an eosinophilic gastritis (EG) status in a subject, wherein the status comprises distinguishing EG from a normal condition defined as the absence of eosinophilic gastrointestinal disease or from eosinophilic esophagitis (EoE), the method comprising:

• applying a gastric tissue sample from the subject to a diagnostic panel for detecting at least one marker or gene selected from Table 9 and/or Table 10, the at least one marker or gene being Dual oxidase 2 (“DUOX2 ”, SEQ ID NO:
• 5), to obtain a result;
• analyzing the result to determine a level of expression of the at least one marker or gene;
• and
• determining the EG status of the subject based upon the level of expression,
• wherein an increased level of DUOX2 expression indicates a status of EG as distinguished from the normal condition or EoE, and wherein an increased expression of any additional markers or genes selected from Table 9, and/or a decreased expression of any additional markers or genes selected from Table 10, indicates a status of EG as distinguished from the normal condition or EoE.