Recognition-release nanoporous substrate comprising active agents, methods of their preparation and uses
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsItamar Willner, Zhang Zhanxia, Dora Balogh
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Abstract
The present invention relates to a porous substrate comprising at least one active agent entrapped within said pores of said substrate; wherein said pores are capped by at least one nucleic acid sequence; said agent is being released by a triggered reaction of said capping sequence with at least one analyte (biomarker) thereby allowing said capping to be cleaved from said pore. The invention further relates to methods of manufacturing said substrate, uses thereof for the controlled administration of active agents and diagnostic of conditions in a patient.
Claims16
A porous substrate comprising pores and at least one active agent entrapped within the pores of said porous substrate;
- at least one capping nucleic acid sequence in a locked conformation capping said pores and entrapping said at least one active agent within said pores;
- said capping nucleic acid sequence, upon association with at least one first analyte changes conformation to form a cleavage-prone conformation, is capable of being cleaved by a biocatalyst thereby allowing the release of said entrapped at least one active agent.
Dependencies are inferred from the claim text.