Recombinant adeno-associated vectors for targeted treatment

A method for transduction of a cell, the method comprising contacting the cell with an rAAV vector comprising a capsid protein comprising an amino acid sequence having at least 95% sequence identity with the amino acid sequence of amino acids 138-736 of SEQ ID NO:2, wherein:

• the amino acid in the capsid protein corresponding to amino acid 151 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 160 of SEQ ID NO:
• 2 is D;
• the amino acid in the capsid protein corresponding to amino acid 206 of SEQ ID NO:
• 2 is C;
• the amino acid in the capsid protein corresponding to amino acid 296 of SEQ ID NO:
• 2 is H;
• the amino acid in the capsid protein corresponding to amino acid 312 of SEQ ID NO:
• 2 is Q;
• the amino acid in the capsid protein corresponding to amino acid 346 of SEQ ID NO:
• 2 is A;
• the amino acid in the capsid protein corresponding to amino acid 464 of SEQ ID NO:
• 2 is N;
• the amino acid in the capsid protein corresponding to amino acid 468 of SEQ ID NO:
• 2 is S;
• the amino acid in the capsid protein corresponding to amino acid 501 of SEQ ID NO:
• 2 is I;
• the amino acid in the capsid protein corresponding to amino acid 505 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 590 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 626 of SEQ ID NO:
• 2 is G or Y;
• the amino acid in the capsid protein corresponding to amino acid 681 of SEQ ID NO:
• 2 is M;
• the amino acid in the capsid protein corresponding to amino acid 687 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 690 of SEQ ID NO:
• 2 is K;
• the amino acid in the capsid protein corresponding to amino acid 706 of SEQ ID NO:
• 2 is C;
• or, the amino acid in the capsid protein corresponding to amino acid 718 of SEQ ID NO:
• 2 is G, and wherein the cell is transduced by the rAAV.

A method for transduction of a cell, the method comprising contacting the cell with an rAAV vector comprising a capsid protein comprising an amino acid sequence having at least 95% sequence identity with the amino acid sequence of amino acids 1-736 of SEQ ID NO:2, wherein:

• the amino acid in the capsid protein corresponding to amino acid 2 of SEQ ID NO:
• 2 is T;
• the amino acid in the capsid protein corresponding to amino acid 65 of SEQ ID NO:
• 2 is I;
• the amino acid in the capsid protein corresponding to amino acid 68 of SEQ ID NO:
• 2 is V;
• the amino acid in the capsid protein corresponding to amino acid 77 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 119 of SEQ ID NO:
• 2 is L;
• the amino acid in the capsid protein corresponding to amino acid 151 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 160 of SEQ ID NO:
• 2 is D;
• the amino acid in the capsid protein corresponding to amino acid 206 of SEQ ID NO:
• 2 is C;
• the amino acid in the capsid protein corresponding to amino acid 296 of SEQ ID NO:
• 2 is H;
• the amino acid in the capsid protein corresponding to amino acid 312 of SEQ ID NO:
• 2 is Q;
• the amino acid in the capsid protein corresponding to amino acid 346 of SEQ ID NO:
• 2 is A;
• the amino acid in the capsid protein corresponding to amino acid 464 of SEQ ID NO:
• 2 is N;
• the amino acid in the capsid protein corresponding to amino acid 468 of SEQ ID NO:
• 2 is S;
• the amino acid in the capsid protein corresponding to amino acid 501 of SEQ ID NO:
• 2 is I;
• the amino acid in the capsid protein corresponding to amino acid 505 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 590 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 626 of SEQ ID NO:
• 2 is G or Y;
• the amino acid in the capsid protein corresponding to amino acid 681 of SEQ ID NO:
• 2 is M;
• the amino acid in the capsid protein corresponding to amino acid 687 of SEQ ID NO:
• 2 is R;
• the amino acid in the capsid protein corresponding to amino acid 690 of SEQ ID NO:
• 2 is K;
• the amino acid in the capsid protein corresponding to amino acid 706 of SEQ ID NO:
• 2 is C;
• or, the amino acid in the capsid protein corresponding to amino acid 718 of SEQ ID NO:
• 2 is G, and wherein the cell is transduced by the rAAV.