Lipohillic oligonucleotide analogs

A lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula I

• with
• Oligonucleotide=an unmodified or modified nucleic acid of 2-1000 nucleotides in length
• R=a bond or a linker unit
• Y=OH, SH or NH substituted with one residue comprising hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms
• X and Z=independently O, S or N, substituted with one residue comprising hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms
• R1, R2=branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the proviso that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond.