Baulamycins, compositions and methods of use thereof
AssigneesThe Regents of the University of Michigan, Asociacion Instituto Nacional De Biodiversidad
InventorsDavid H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz
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Abstract
Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
Claims6
A method of inhibiting a nonribosomal peptide synthetase independent siderophore (NIS) synthetase comprising contacting the NIS synthetase with a composition comprising a pharmaceutically acceptable excipient and a compound of formula (I), or a pharmaceutically acceptable salt thereof,
- wherein R1 is a C1-6alkyl;
- said composition contacted in an amount sufficient to inhibit the NIS synthetase.
Dependencies are inferred from the claim text.