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AssigneesInstitut Curie, Centre National de la Recherche Scientifique (CNRS), Societe De Developpement Et De Recherche Industrielle
InventorsMael Le Berre, Matthieu Piel, Yong Chen, Yanjun Liu
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The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.
A method for guiding cell migration, comprising bringing the cells into contact with a substrate having a textured surface which has an anisotropic three-dimensional structure, said structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured surface, in the direction imparted by said anisotropic structure, said projections having a regular spacing which is smaller than the diameter of the cells, wherein the cells are conveyed on a support surface, and wherein said support surface and/or said textured surface comprises one or more additional protuberances which make it possible to control the distance between the two said surfaces.
Dependencies are inferred from the claim text.