Anti-human receptor-type protein tyrosine phosphatase sigma antibody
AssigneeSBI Biotech Co., Ltd.
InventorsTomohide Yamazaki, Jing Zhao, Koji Ishida, Yasue Shibata, Minkwon Cho, Mayuki Endo
Life of this patent
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Abstract
A monoclonal antibody that binds to an extracellular domain of human receptor-type protein tyrosine phosphatase σ (human PTPRS), or a fragment including an antigen-binding region thereof.
Claims10
A monoclonal antibody produced by hybridoma 9H5-4 that was deposited as Accession No. FERM BP-11356, hybridoma 10F7-38 that was deposited as Accession No. FERM BP-11357, hybridoma 13G5-52 that was deposited as Accession No. FERM BP-11358, hybridoma 13G5-57 that was deposited as Accession No. FERM BP-11359, hybridoma 14A8-85 that was deposited as Accession No. FERM BP-11360, hybridoma 22H8-84 that was deposited as Accession No. FERM BP-11361, hybridoma 49F2-30 that was deposited as Accession No. FERM BP-11362 or hybridoma 55E7-79 that was deposited as Accession No. FERM BP-11363, or an antigen-binding fragment thereof.
Hybridoma 9H5-4 deposited as Accession No. FERM BP-11356, hybridoma 10F7-38 deposited as Accession No. FERM BP-11357, hybridoma 13G5-52 deposited as Accession No. FERM BP-11358, hybridoma 13G5-57 deposited as Accession No. FERM BP-11359, hybridoma 14A8-85 deposited as Accession No. FERM BP-11360, hybridoma 22H8-84 deposited as Accession No. FERM BP-11361, hybridoma 49F2-30 deposited as Accession No. FERM BP-11362 or hybridoma 55E7-79 deposited as Accession No. FERM BP-11363.
An antibody or antigen-binding fragment thereof that binds to human receptor-type protein tyrosine phosphatase σ (human PTPRS), comprising:
- a heavy chain CDR1 set forth in SEQ ID NO:45, a heavy chain CDR2 set forth in SEQ ID NO:46, a heavy chain CDR3 set forth in SEQ ID NO:47, a light chain CDR1 set forth in SEQ ID NO:50, a light chain CDR2 set forth in SEQ ID NO:51, and a light chain CDR3 set forth in SEQ ID NO:52;
- a heavy chain CDR1 set forth in SEQ ID NO:55, a heavy chain CDR2 set forth in SEQ ID NO:56, a heavy chain CDR3 set forth in SEQ ID NO:57, a light chain CDR1 set forth in SEQ ID NO:60, a light chain CDR2 set forth in SEQ ID NO:61, and a light chain CDR3 set forth in SEQ ID NO:62;
- a heavy chain CDR1 set forth in SEQ ID NO:65, a heavy chain CDR2 set forth in SEQ ID NO:66, a heavy chain CDR3 set forth in SEQ ID NO:67, a light chain CDR1 set forth in SEQ ID NO:70, a light chain CDR2 set forth in SEQ ID NO:71, and a light chain CDR3 set forth in SEQ ID NO:72;
- or
- a heavy chain CDR1 set forth in SEQ ID NO:27, a heavy chain CDR2 set forth in SEQ ID NO:28, a heavy chain CDR3 set forth in SEQ ID NO:29, a light chain CDR1 set forth in SEQ ID NO:32, a light chain CDR2 set forth in SEQ ID NO:33, and a light chain CDR3 set forth in SEQ ID NO:34.
An antibody or antigen-binding fragment thereof that binds to human receptor-type protein tyrosine phosphatase σ (human PTPRS), wherein the antibody or antigen-binding fragment thereof comprises the heavy and light chain complementarity determining regions of the antibody produced by hybridoma 9H5-4 (deposited as Accession No. FERM BP-11356), hybridoma 10F7-38 (deposited as Accession No. FERM BP-11357), hybridoma 13G5-52 (deposited as Accession No. FERM BP-11358), hybridoma 13G5-57 (deposited as Accession No. FERM BP-11359), hybridoma 14A8-85 (deposited as Accession No. FERM BP-11360), hybridoma 22H8-84 (deposited as Accession No. FERM BP-11361), hybridoma 49F2-30 (deposited as Accession No. FERM BP-11362), or hybridoma 55E7-79 (deposited as Accession No. FERM BP-11363).
Dependencies are inferred from the claim text.