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US 9,803,023 B2Granted
Fc variants with altered binding to FcRn
AssigneeXencor, Inc.
InventorsAaron Keith Chamberlain, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Jost Vielmetter, Sean C. Yoder
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Abstract
The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
Claims9
A polypeptide comprising an Fc variant of a human IgG Fc polypeptide, wherein said Fc variant comprises a serine at position 434, and wherein numbering is according to the EU index in Kabat et al.
Dependencies are inferred from the claim text.