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US 9,803,019 B2Granted
Carrier immunoglobulins and uses thereof
AssigneeAmgen Inc.
InventorsKenneth W. Walker, Frederick W. Jacobsen, Taruna Arora
Life of this patent
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Abstract
Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
Claims26
An isolated immunoglobulin, comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein:
- (a) the light chain variable region comprises the amino acid sequence of SEQ ID NO:196 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:335, SEQ ID NO:349, SEQ ID NO:351, SEQ ID NO:353, SEQ ID NO:355, or SEQ ID NO:359, or
- (b) the light chain variable region comprises the amino acid sequence of SEQ ID NO:204 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:349 or SEQ ID NO:355, or
- (c) the light chain variable region comprises the amino acid sequence of SEQ ID NO:202 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:349, or
- (d) the light chain variable region comprises the amino acid sequence of SEQ ID NO:192 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:357, SEQ ID NO:359, or SEQ ID NO:369, or
- (e) the light chain variable region comprises the amino acid sequence of SEQ ID NO:194 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:335, SEQ ID NO:349, or SEQ ID NO:351.
2 more elements
Dependencies are inferred from the claim text.