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US 9,803,017 B2Granted
Soluble MIC neutralizing monoclonal antibody for treating cancer
AssigneeUniversity of Washington through its Center for Commercialization
InventorJennifer Wu
Life of this patent
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Abstract
Disclosed are compositions and methods relating to antibodies that bind soluble Major Histocompatibility Complex class I chain-related (sMIC). Specifically, disclosed are antibodies designed or selected to inhibit sMIC (e.g. to neutralize sMIC) shed from MIC+ tumors. Further disclosed are methods of using the antibodies for the treatment of MIC-positive cancers.
Claims16
An isolated antibody or antigen-binding portion thereof that specifically binds to a sMIC polypeptide comprising heavy and light chain complementarity determining regions (CDRs):
- a. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 9;
- b. a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 10;
- c. a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 11;
- d. a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 12;
- e. a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 13;
- and
- f. a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 14.
10 more elements
Dependencies are inferred from the claim text.