Anti-CD47 antibodies and methods of use
AssigneesErasmus University Medical Center, Surface Oncology, Inc.
InventorsFrank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
Life of this patent
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Abstract
Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
Claims30
An isolated monoclonal antibody that specifically binds human CD47, or antigen binding fragment thereof, wherein the monoclonal antibody or antigen binding fragment thereof comprises:
- a heavy chain complementarity determining region 1 (HC CDR1) comprising the amino acid sequence set forth in SEQ ID NO:
- 7;
- a heavy chain complementarity determining region 2 (HC CDR2) comprising the amino acid sequence set forth in SEQ ID NO:
- 8;
- a heavy chain complementarity determining region 3 (HC CDR3) comprising the amino acid sequence set forth in SEQ ID NO:
- 9;
- a light chain complementarity determining region 1 (LC CDR1) comprising the amino acid sequence set forth in SEQ ID NO:
- 10;
- a light chain complementarity determining region 2 (LC CDR2) comprising the amino acid sequence set forth in SEQ ID NO:
- 11;
- and
- a light chain complementarity determining region 3 (LC CDR3) comprising the amino acid sequence set forth in SEQ ID NO:
- 12.
An isolated monoclonal antibody that specifically binds human CD47 or an antigen-binding fragment thereof, wherein the monoclonal antibody comprises a heavy chain variable region (VH) comprising the amino acid sequence set forth in SEQ ID NO:
- 4 and a light chain variable region (VL) comprising the amino acid sequence set forth in SEQ ID NO:
- 6.
An isolated monoclonal antibody that specifically binds human CD47, wherein the monoclonal antibody comprises:
- a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:
- 15, SEQ ID NO:
- 23, SEQ ID NO:
- 24, or SEQ ID NO:
- 25;
- and a light chain comprising the amino acid sequence set forth in SEQ ID NO:
- 16 or SEQ ID NO:
- 26.
An isolated monoclonal antibody that specifically binds human CD47, wherein the monoclonal antibody comprises:
- a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:
- 24;
- and a light chain comprising the amino acid sequence set forth in SEQ ID NO:
- 26.
Dependencies are inferred from the claim text.