Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
AssigneeMayo Foundation for Medical Education and Research
InventorsLieping Chen, Scott E. Strome, Eugene D. Kwon
Life of this patent
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Abstract
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
Claims7
A method for treating an immunosuppression characterized by an impaired function and survival of activated tumor-specific T-cells in a subject with cancer comprising administering, to said subject, an agent which is an antibody or an antigen-binding antibody fragment that interferes with an interaction between B7-H1 and a receptor for B7-H1, wherein some or all cells of said cancer express B7-H1, wherein said subject is a human and said B7-H1 is human B7-H1 (hB7-H1), wherein said agent binds to hB7-H1, and wherein said cancer is a renal cell carcinoma.
Dependencies are inferred from the claim text.