JAM-C antibodies and methods for treatment of cancer
AssigneeResearch Development Foundation
InventorsBeat Imhof, Christiane Ody, Thomas Matthes, Carmen Donate
Life of this patent
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Abstract
A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In certain aspects, a method for identifying and treating JAM-C positive B-cell lymphoma patients with anti-JAM-C antibodies is provided. Recombinant antibody molecules that specifically bind to JAM-C are also disclosed.
Claims12
A method for decreasing long-term B-cell lymphoma engraftment in a patient having a JAM-C positive B-cell lymphoma comprising administering an amount of a monoclonal JAM-C-binding antibody effective to decrease long-term lymphoma engraftment in the patient.
Dependencies are inferred from the claim text.