Biological materials and uses thereof
AssigneeBioinvent International AB
InventorsBjörn Frendéus, Roland Carlsson, Ingrid Teige, Linda Mårtensson
Life of this patent
Estimating the term…
Abstract
The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce cell death of the target cell. There is also provided methods of and pharmaceutical compositions for cell death induction and uses thereof.
Claims15
An antibody which selectively binds to cell surface ICAM-1 and, on binding ICAM-1, induces Fc-FcγR-dependent cell death of a target cell in vivo, wherein the antibody comprises variable regions having the sequences of SEQ ID NOs:
- 6 and 8.
An in vivo method of inducing Fc-FcγR-dependent cell death in a target cell, the method comprising:
- a. providing one or more target cells displaying cell surface antigen ICAM-1;
- b. providing one or more antibodies which selectively binds to cell surface antigen ICAM-1, and, on binding ICAM-1, induces Fc-FcγR-dependent cell death of the target cell;
- c. exposing the target cells to the antibodies to induce Fc-FcγR-dependent cell death of the target cells,
- wherein the antibodies comprise variable regions having the sequences of SEQ ID NOs:
- 6 and 8.
A method of diagnosing, or treating an ICAM-1-associated disease in a subject in need thereof, the method comprising administering to the subject an antibody which selectively binds to cell surface antigen ICAM-1, and, on binding ICAM-1, induces Fc-FcγR-dependent cell death of a target cell, wherein the method requires the destruction of the target cell, and wherein the antibody comprises variable regions having the sequences of SEQ ID NOs:
- 6 and 8.
Dependencies are inferred from the claim text.