Anti-hepcidin antibodies and uses thereof
AssigneeIntrinsic Lifesciences LLC
InventorsMark Westerman, Vaughn Ostland, Huiling Han, Patrick Gutschow, Keith Westerman, Gordana Olbina
Life of this patent
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Abstract
The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies which bind hepcidin and regulate iron homeostasis. Another aspect relates to the use of humanized antibodies which bind hepcidin for the treatment of a disease or condition associated with hepcidin.
Claims28
An antibody, or antigen-binding fragment thereof, that specifically binds to hepcidin (Hep) or a hepcidin peptide, wherein the antibody, or antigen-binding fragment thereof, comprises a heavy chain CDR1 encoded by SEQ ID NO:
- 57, a heavy CDR2 encoded by SEQ ID NO:
- 60, a heavy chain CDR3 encoded by SEQ ID NO:
- 63, a light chain CDR1 encoded by SEQ ID NO:
- 66, a light CDR2 encoded by SEQ ID NO:
- 69, and a light chain CDR3 encoded by SEQ ID NO:
- 72.
An antibody, or antigen-binding fragment thereof, that specifically binds to hepcidin or a hepcidin peptide, that comprises a heavy chain variable region having an amino acid sequence of SEQ ID NO:
- 46 and a light chain variable region having an amino acid sequence of SEQ ID NO:
- 52.
Dependencies are inferred from the claim text.