Immunobinders directed against TNF
AssigneeAbbVie Inc.
InventorsChung-Ming Hsieh, Lorenzo Benatuil, Yuliya Kutskova, John Memmott, Jennifer Perez, Suju Zhong, Carrie Goodreau, Anca Clabbers
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Abstract
Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Claims12
A binding protein that binds human TNF-α, the binding protein comprising at least one heavy chain variable region (VH region) and at least one light chain variable region (VL region), wherein
- the VH region comprises the amino acid sequence of SEQ ID NO:
- 74 and
- the VL region comprises the amino acid sequence of SEQ ID NO:
- 84.
Dependencies are inferred from the claim text.