Humaneered anti-factor B antibody

A humaneered anti-factor B antibody or antigen-binding fragment thereof that selectively binds to factor B within the third short consensus repeat (“SCR”) domain and prevents formation of the C3bBb complex, wherein the humaneered anti-factor B antibody or antigen-binding fragment thereof has an equilibrium dissociation constant (“KD”) between about 1.0×10−8 M and about 1.0×10−10 M, wherein the humaneered anti-factor B antibody or antigen-binding fragment thereof lacks a glycosylation site in its light chain and exhibits comparable or higher binding affinity relative to an unmodified humaneered anti-factor B antibody or antigen-binding fragment thereof, and wherein the humaneered anti-factor B antibody or antigen-binding fragment thereof comprises:

• i) the VK domain sequence of SEQ ID NO:
• 3 and the VH domain sequence of SEQ ID NO:
• 5 or 4;
• ii) the light chain sequence of SEQ ID NO:
• 8 and the heavy chain sequence of SEQ ID NO:
• 10 or 9;
• iii) the VK domain sequence of SEQ ID NO:
• 2 and the VH domain sequence of SEQ ID NO:
• 5 or 4;
• or
• iv) the light chain sequence SEQ ID NO:
• 7 and the heavy chain sequence SEQ ID NO:
• 10 or 9.